ABSTRACT
Purpose: For purpose of SARS-CoV-2 infection control, vaccination was started in worldwide, however, low reactivity of antibody production after vaccination is a concern for solid organ transplant (SOT) recipients. In general, antibody titers would be peaked within one month after vaccination for the healthy population, there are few report about SOT recipients vaccination. We explored antibody transitions in SOT recipients after vaccination. Method(s): A total of 641 solid organ transplant recipients were enrolled (481 kidney, 51 liver, 54 heart, 20 lung, and 35 simultaneous pancreas-kidney). All participants were administered the two-dose regimen mRNA vaccine (BNT162b2, Pfizer or mRNA-1273, Moderna), as indicated. SARS-CoV-2 antibodies were measured total 5 times throughout vaccination (Elecsys, Roche). Result(s): The antibody titer and positive rate were both elevated until three months and declined at six months after vaccination (positive rate;10.4%, 41.2%, 68.6%, 56.9%, in each) (Fig.1). Lung and kidney-pancreas transplant recipients showed poor antibody titer elevation compared with other organ transplantation (Fig. 2). Antibody titers be significant low by more than 60 years old compared with other ages (Fig.3). Conclusion(s): The antibody titer and positive rate transition of SOT recipients were quite different compared with the health population. The acquisition of antibody was different depends on type of SOT. (Figure Presented).
ABSTRACT
Purpose: We examined a positivity of corona virus antibody in kidney transplant recipients who received two-doses BNT162B2 (mRNA) vaccination during the beginning 6 months in 2021. Method(s): The subjects include 111 kidney transplant recipients who received two-doses BNT162B2 (mRNA) vaccination, consisting of 61 male and 50 females, 53.7+/-14.7 years old on average. Healthy 10 volunteers were also enrolled in this study as a control group. We adopted LABScreen COVID plus beads (One Lambda) as an antibody reagent to detect antibodies against corona viruses including 5 types structural proteins such as extracellular domain (ECD), Spike 1, Spike 2, receptorbinding domain (RBD) and nucleoside. Result(s): Among 111 recipients, 46 recipients showed positivity (41%), whilst all control showed positivity (100%). Among 100 recipients taking tacrolimus, 37 recipients showed positivity, although 9 recipients out of 10 taking cyclosporine showed positivity (90%). It is noteworthy that recipients receiving rituximab (CD20 antibody) significantly shows lower rate of antibody positivity. The period between vaccination and rituximab administration is closely related to the positivity of antibody positivity. In recipients without rituximab administration, lower trough level for tacrolimus and MMF is related to higher positivity of antibody production. Positivity pattern in 5 protein fragments shows individually various different in transplant recipients, while it shows stable pattern in healthy volunteers. Conclusion(s): Kidney transplant recipients showed lower positivity of corona virus antibody compared to healthy volunteers, which is deeply related to immunosuppression in the past. This assay in this study yields reproductive excellent results for corona virus antibody. The assay helps us to find the appropriate booster vaccination time and doses on the basis of these past results. (Figure Presented).
ABSTRACT
The COVID-19 pandemic has increased the incidence of serious social mental health problems such as depression. Changes to the way we work, such as telework, are potential factors for mental health problems. This study’s aim was to investigate the relationship between difficulties adjusting to new work styles and depression among job workers during the first wave of the COVID-19 pandemic. We conducted a web-questionnaire survey of 919 Japanese workers (May 2020) using the snowball sampling method. A hierarchical logistic regression analysis using a dependent variable (depression), an independent variable (difficulty in work practices), and adjustment variables (gender, age, working practices, and coping) found that those who had difficulty “communicating with boss, colleagues, and subordinates” and “switching on and off” were more likely to be depressed. This study shows that there was a relationship between difficulty in work practices and depression during the pandemic. Given this study’s limitations, it is hoped that the influence of region and occupation on depression will be examined by recruiting a wide range of participants in the future. © 2022 Japanese Psychological Association. All rights reserved.
ABSTRACT
Purpose: The novel coronavirus 2019 infection (COVID-19) caused a pandemic, prompting Tokyo, Japan, to restrict on the free movement of people in March 2020. Kidney transplant recipients are at high risk for critical COVID-19 due to chronic immunosuppression and coexisting conditions. For the follow-up of kidney transplant recipients during this pandemic, the number of hospital visits or use remote counseling should be reduced to minimize the risk of infection. However, the management of kidney transplant recipients during the COVID-19 pandemic is uncertain. Methods: This single-center retrospective observational study included 980 patients who, more than a year previously, had undergone kidney transplantation and were taking extended-release tacrolimus once a day, with a target trough level of 4 to 6 ng/ml. We evaluated the effects of coronavirus pandemic on clinical outcomes such as tacrolimus blood level, renal function, and rejection in kidney transplant recipients, comparing pandemic data with non-pandemic data obtained between September 2019 and August 2020 in our hospital. Results: Comparing pandemic data with non-pandemic data, the mean interval between hospital visits was 5.5±2.6 vs. 7.3±4.5 weeks (P=2.68×10-14). Serum Cr levels and rejection rates after kidney transplant showed no significant differences between both groups. There were no significantly differences in the coefficient of variation (CV) in tacrolimus blood levels, the rate of changes in oral medication, and the rate of deviation from the target trough level during the pandemic. Conclusions: In kidney transplant recipients, blood levels of tacrolimus were maintained at target trough levels during the COVID-19 pandemic.